Fred K. Gruber is a senior principal scientist at Aitia. At Aitia he applies statistical and machine learning techniques for the development of models from biological data (genomic and clinical) with special attention to interpretation of the resulting models. His expertise goes beyond the usual machine learning topics (logistic regression, Neural Networks, Support Vector Machine, Genetic Algorithms) to include other techniques like statistical signal processing (random processes, optimal filters, Bayesian estimation), inverse problem theory (regularized least square solutions, pseudoinverse), sparse coding (sparse reconstruction, dictionary learning), and simulation and modeling (discrete event simulation, statistical modeling).
Target Trial Emulation, 2022
Harvard University
Applied Deep Learning Boot Camp, 2020
Massachusetts Institute of Technology
An Introduction to Causal Inference, 2018
Harvard University
Data Science: Data to Insights, 2016
Massachusetts Institute of Technology
PhD in Electrical Engineering, 2009
Northeastern University
BSc in Electrical and Electronic Engineering, 2003
Universidad Tecnologica de Panama
100%
50%
50%
70%
60%
90%
My focus is in applying causal inference and causal discovery methods on multiple modalities of biological data including RNAseq (single and bulk), single nucleotides variants (germline and somatic), structural variants, copy number variants as well as clinically relevant variables for the purpose of discovering biomarkers and drug targets of various diseases. More recently I have worked with multiple myeloma clinical studies as well as the TCGA cancer datasets. While I mainly work with our proprietary causal Bayesian network learning and predictive tools as part of my job I also investigate other open source machine learning tools that have potential usage for the type of datasets that we deal with.
Responsibilities:
I designed, implemented and tested novel algorithms for the analysis of Nuclear Magnetic Resonance measurements of rocks and fluids that are of interest in oil exploration. I use Matlab extensively for the research and Python in order to interface Matlab code with other company software.
Responsibilities included:
Worked at the Center for NASA Simulation Research Group where I was involved in several projects including: